FACCE-JPI in collaboration with the ERA-Net Cofund on Sustainable Crop Production (SusCrop) organised a two-day workshop “Application of Novel Breeding Techniques in crops in the context of food security and Climate Change”, hosted by INIA. The aim of the workshop was to assess the current state-of-the-art of novel breeding techniques in crops and to identify major challenges and opportunities in the light of food security and climate change. The event brought together 42 experts from 16 countries representing different involved sectors and actors. The workshop sessions included key speakers’ introductory lectures to address the research, stakeholders, end-users and policy perspective followed by breakout sessions focused on gap/limitations and opportunities/strengths group discussion on relevant key subtopics. The conclusion and plenary discussion addressed the identification of specific recommendations for FACCE-JPI future contributions and actions in this field.